Bioactivity:

GN44028 is an inhibitor of HIF-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1_ transcriptional activity. However, It can not be suppressing HIF-1_ mRNA expression, HIF-1_ protein accumulation, or HIF-1_/HIF-1_ heterodimerization.

CAS nr:

1421448-26-1

Purity:

98%

Molecular Weight:

305,33

SMILES:

C1(NC2=CC=C(OCCO3)C3=C2)=NNC4=C1CC5=CC=CC=C45

Formula:

C18H15N3O2

Pathway:

Angiogenesis,Chromatin/Epigenetic

Target:

HIF,HIF