Bioactivity:

CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKC_ with IC50s of 3.1 _M , 2.3 _M, 1.4 _M and

CAS nr:

865608-11-3

Purity:

98%

Molecular Weight:

466,46

SMILES:

CN1C(=NN=C1C2=CC=NC=C2)CNC3=CC=CC(=C3)C(=O)NCC4=CC=CC=C4C(F)(F)F

Formula:

C24H21F3N6O

Pathway:

Cytoskeletal Signaling,Chromatin/Epigenetic,Stem Cells,Cytoskeletal Signaling,Cell Cycle/Checkpoint,GPCR/G Protein

Target:

PKC,PKC,ROCK,ROCK,ROCK,GRK