Bioactivity:

GS143 is a selec_tive I_B_ ubiquitination inhibitor with an IC50 of 5.2 _M for SCF_TrCP1-mediated I_B_ ubiquitylation. GS143 sup_presses NF-_B acti_va_tion and tran_scrip_tion of tar_get genes and does not inhibit proteasome activity. GS143 has anti-asthm

CAS nr:

916232-21-8

Purity:

98%

Molecular Weight:

466,46

SMILES:

OC(c(cc1)ccc1N(C1=O)N=C(Cc2ccccc2)C1=Cc1ccc(-c(cccc2)c2F)o1)=O

Formula:

C28H19FN2O4

Pathway:

NF-_b,NF-_b,Ubiquitination

Target:

NF-_B,I_B/IKK,E1/E2/E3 Enzyme