Bioactivity:

Talmapimod hydrochloride is a selective and ATP-competitive p38_ inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38_, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.

CAS nr:

309915-12-6

Purity:

98%

Molecular Weight:

549,46

SMILES:

O=C(N(C)C)C(C1=CN(C)C2=C1C=C(C(N3[C@H](C)CN(CC4=CC=C(F)C=C4)[C@@H](C)C3)=O)C(Cl)=C2)=O.[H]Cl

Formula:

C27H31Cl2FN4O3

Pathway:

MAPK

Target:

p38 MAPK