Bioactivity:

Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1].

CAS nr:

2126819-55-2

Purity:

98%

Molecular Weight:

387,46

SMILES:

CC1=NN=C2COCC(C(CC3=CC=CC=C3)=C(C#CC4=CNN=C4)S5)=C5N21

Formula:

C21H17N5OS

Pathway:

Others

Target:

Others