Bioactivity:

A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12, IC50: 18 nM).

CAS nr:

2089148-72-9

Purity:

98%

Molecular Weight:

486,65

SMILES:

O=S(N1CCN(C2=CC=C([C@H]3CN(C4C(C(F)=CC=C5)=C5CC4)C[C@@H]3N(C)C)C=C2)CC1)(C)=O

Formula:

C26H35FN4O2S

Pathway:

Chromatin/Epigenetic

Target:

Histone Methyltransferase