Bioactivity:

WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3K_ (>100-fold) and PI3K_ (>500-fold).

CAS nr:

1062159-35-6

Purity:

98%

Molecular Weight:

494,59

SMILES:

C(N1CCC(CC1)N1N=CC2=C1N=C(N=C2N1CCOCC1)C1=CC2=C(NC=C2)C=C1)C1=CC=CN=C1

Formula:

C28H30N8O

Pathway:

PI3K/Akt/mTOR signaling,Tyrosine Kinase/Adaptors,Angiogenesis,PI3K/Akt/mTOR signaling,Tyrosine Kinase/Adaptors,Angiogenesis

Target:

PI3K,VEGFR,VEGFR,mTOR,Src,Src