Bioactivity:

TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM).�It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

CAS nr:

1638211-05-8

Purity:

98%

Molecular Weight:

305,59

SMILES:

NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1.[H]Cl

Formula:

C11H11Cl3N4

Pathway:

DNA Damage/DNA Repair,Cell Cycle/Checkpoint,DNA Damage/DNA Repair

Target:

MTH1,DNA/RNA Synthesis,DNA/RNA Synthesis