Bioactivity:

BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM.�It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).

CAS nr:

2519823-34-6

Purity:

98%

Molecular Weight:

837,38

SMILES:

O=C(NCCCCCCCN1C[C@H](NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(C(C)C)=O)=N2)CCC1)COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O

Formula:

C40H49ClN8O8S

Pathway:

Cell Cycle/Checkpoint

Target:

CDK