Bioactivity:

Edicotinib is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the potential for Alzheimer's disease and rheumatoid

CAS nr:

1142363-52-7

Purity:

98%

Molecular Weight:

461,6

SMILES:

CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)OC(C)(C)C1

Formula:

C27H35N5O2

Pathway:

Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors

Target:

CSF-1R,c-Kit,c-Fms,FLT,FLT