Bioactivity:

LGK-974 is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck.

CAS nr:

1243244-14-5

Purity:

98%

Molecular Weight:

396,44

SMILES:

Cc1nccc(c1)c1c(C)cc(CC(=O)Nc2ncc(cc2)c2nccnc2)cn1

Formula:

C23H20N6O

Pathway:

Stem Cells

Target:

Porcupine