Bioactivity:

dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.

CAS nr:

1799711-21-9

Purity:

98%

Molecular Weight:

785,27

SMILES:

Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1

Formula:

C38H37ClN8O7S

Pathway:

Chromatin/Epigenetic

Target:

Epigenetic Reader Domain