Bioactivity:

GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of th

CAS nr:

2490599-18-1

Purity:

98%

Molecular Weight:

861,93

SMILES:

CC1=C(SC=N1)C1=CC=C(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)COCCOC2=CC=C(C=C2)C2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)C(C)(C)C)C=C1

Formula:

C43H4F3NOS

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling

Target:

Bcr-Abl,Bcr-Abl,Bcr-Abl