Bioactivity:

ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFR_/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).

CAS nr:

1357470-29-1

Purity:

98%

Molecular Weight:

429,52

SMILES:

CN1CCN(CC1)C1=CC=C(NC2=NC=C3C=C(C#N)C(=O)N(C4CCCC4)C3=N2)C=C1

Formula:

C24H27N7O

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,PI3K/Akt/mTOR signaling,Tyrosine Kinase/Adaptors,Apoptosis,Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic,Stem Cells,Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Cell Cycle/Checkpoint

Target:

PDGFR,PDGFR,AMPK,c-RET,c-RET,JAK,JAK,JAK,JAK,FGFR,Src,Src,FGFR,CDK