Bioactivity:

PIK-75 Hydrochloride is a p110_ inhibitor with IC50 of 5.8 nM (200-fold more potently than p110_), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.

CAS nr:

372196-77-5

Purity:

98%

Molecular Weight:

488,74

SMILES:

Cc1ccc(cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(cn12)Br)[N+](=O)[O-].Cl

Formula:

C16H14BrN5O4S�HCl

Pathway:

PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,DNA Damage/DNA Repair,Apoptosis

Target:

PI3K,DNA-PK,DNA-PK,Apoptosis