Entrectinib T3678
Specifications
| 1mg/5mg/10mg/25mg/50mg/100mg |
Bioactivity:
Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectinib blocks proliferation of ALK-dependent cell l
CAS nr:
1108743-60-7
Purity:
98%
Molecular Weight:
560,64
SMILES:
CN1CCN(CC1)c1cc(c(cc1)C(=O)Nc1n[nH]c2c1cc(cc2)Cc1cc(cc(c1)F)F)NC1CCOCC1
Formula:
C31H34F2N6O2
Pathway:
Angiogenesis,Immunology/Inflammation,Tyrosine Kinase/Adaptors,Autophagy,Tyrosine Kinase/Adaptors
Target:
ALK,ROS,ALK,Autophagy,Trk receptor
