Bioactivity:

Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), RO

CAS nr:

1206801-37-7

Purity:

98%

Molecular Weight:

625,45

SMILES:

[H]Cl.[H]Cl.O=C(C1=CC=C(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC5=C(N(C)N=C5)C=C4C6=CNN=C6)C(F)=C3

Formula:

C30H24Cl2F2N6O3

Pathway:

Stem Cells,Cytoskeletal Signaling,Cell Cycle/Checkpoint

Target:

ROCK,ROCK,ROCK