Bioactivity:

Pictilisib dimethanesulfonate is a potent inhibitor of PI3K_/_ with IC50 of 3 nM, with modest selectivity against p110_ (11-fold) and p110_ (25-fold).

CAS nr:

957054-33-0

Purity:

98%

Molecular Weight:

705,85

SMILES:

CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6.CS(=O)(=O)O.CS(=O)(=O)O

Formula:

C25H35N7O9S4

Pathway:

PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,DNA Damage/DNA Repair,Autophagy,Apoptosis

Target:

PI3K,mTOR,DNA-PK,DNA-PK,Autophagy,Apoptosis