Bioactivity:

AT9283 is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).

CAS nr:

896466-04-9

Purity:

98%

Molecular Weight:

381,43

SMILES:

O=C(NC1CC1)Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1

Formula:

C19H23N7O2

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Stem Cells,Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic,Cell Cycle/Checkpoint,Autophagy,Chromatin/Epigenetic,Apoptosis,Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling

Target:

FLT,FLT,JAK,JAK,JAK,JAK,Aurora Kinase,Autophagy,Aurora Kinase,Apoptosis,Bcr-Abl,Bcr-Abl,Bcr-Abl