Bioactivity:

PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 antagonist. It also has comparable human and rodent CCR2 potency (rat IC50=20.8 nM). PF-0463481

CAS nr:

1228111-63-4

Purity:

98%

Molecular Weight:

511,58

SMILES:

O=C(N1[C@@]2([H])C[C@@]([H])(C1)N(C3=NC=NC(C(F)(F)F)=C3)C2)[C@@]4(C[C@@H](CC4)N[C@@H]5[C@@H](COCC5)OC)C(C)C

Formula:

C25H36F3N5O3

Pathway:

Microbiology/Virology,Immunology/Inflammation

Target:

CCR,CCR