Bioactivity:

ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (IC50: 0.6 _M). It is also stable in plasma across species.

CAS nr:

1699720-89-2

Purity:

98%

Molecular Weight:

355,43

SMILES:

COC1=CC=C2C(NC3=C2C[C@]4(N([C@H]3CC(C)C)C([C@@H](NC4=O)C)=O)[H])=C1

Formula:

C20H25N3O3

Pathway:

PI3K/Akt/mTOR signaling

Target:

AMPK