Bioactivity:

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50�= 7.71).

CAS nr:

1254980-38-5

Purity:

98%

Molecular Weight:

414,47

SMILES:

FC(C1=C(CN2CCC(C3=CC=CC=C3)CC2)C=CN4C1=NN=C4CC5CC5)(F)F

Formula:

C23H25F3N4

Pathway:

Neuroscience

Target:

GluR