Bioactivity:

7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-_ in EC inhibits NF-kB activity of TNF-_-activated EC which leads to selective inhibition of VCAM-1 expression.

CAS nr:

150972-72-8

Purity:

98%

Molecular Weight:

486,7

SMILES:

C[C@@H]1C[C@H]2O[C@]3(O[C@@H]2C(C)(C)O)[C@H](O)[C@@]2(C)C4=CC[C@@H]5[C@]6(CC46CC[C@]2(C)C13)CC[C@H](O)C5(C)C

Formula:

C30H46O5

Pathway:

Apoptosis,PI3K/Akt/mTOR signaling,NF-_b,NF-_b,Cytoskeletal Signaling,Metabolism,DNA Damage/DNA Repair,MAPK

Target:

TNF,Akt,NF-_B,I_B/IKK,Akt,PPAR,PPAR,ERK