Bioactivity:

COH34 is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50: 0.37 nM). COH34 binds to the catalytic domain of PARG (Kd: 0.547 _M), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.

CAS nr:

906439-72-3

Purity:

98%

Molecular Weight:

293,38

SMILES:

CC1=CC=C(S/N=C/C2=C3C=CC=CC3=CC=C2O)C=C1

Formula:

C18H15NOS

Pathway:

Others

Target:

Others