Bioactivity:

MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C.�It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above the

CAS nr:

2206736-04-9

Purity:

98%

Molecular Weight:

565,71

SMILES:

CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C=C)c1cccc2cccc(C)c12

Formula:

C33H39N7O2

Pathway:

MAPK,GPCR/G Protein

Target:

Ras,Ras