Bioactivity:

Ilorasertib (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppresses RET tyrosine kinase, PDGFR_, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).

CAS nr:

1227939-82-3

Purity:

98%

Molecular Weight:

488,54

SMILES:

Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12

Formula:

C25H21FN6O2S

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Apoptosis,Tyrosine Kinase/Adaptors,Angiogenesis,Chromatin/Epigenetic,Cell Cycle/Checkpoint,Angiogenesis,Tyrosine Kinase/Adaptors

Target:

PDGFR,PDGFR,c-RET,c-RET,VEGFR,VEGFR,Aurora Kinase,Aurora Kinase,FLT,FLT