Bioactivity:

5-Iodo-indirubin-3'-monoxime is a potent GSK-3_, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20 and 25 nM).

CAS nr:

331467-03-9

Purity:

98%

Molecular Weight:

403,17

SMILES:

O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=C(I)C=C4)=O

Formula:

C16H10IN3O2

Pathway:

Cell Cycle/Checkpoint,PI3K/Akt/mTOR signaling,Stem Cells

Target:

CDK,GSK-3,GSK-3