Bioactivity:

Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induce

CAS nr:

500214-53-9

Purity:

98%

Molecular Weight:

421,45

SMILES:

COC1=C(OC)C=C(C(N(CCN(C)C)C2=C3C=NC4=C2C=C(OCO5)C5=C4)=O)C3=C1

Formula:

C23H23N3O5

Pathway:

DNA Damage/DNA Repair

Target:

Topoisomerase