Bioactivity:

Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 28 nM/35 nM/118 nM, respectively.

CAS nr:

1223001-51-1

Purity:

98%

Molecular Weight:

432,4

SMILES:

c1cc(cc(c1)n1c(=O)ccc2cnc3ccc(cc3c12)c1cnc(cc1)N)C(F)(F)F

Formula:

C24H15F3N4O

Pathway:

PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,DNA Damage/DNA Repair,PI3K/Akt/mTOR signaling,DNA Damage/DNA Repair,Apoptosis,Autophagy

Target:

mTOR,DNA-PK,DNA-PK,ATM/ATR,ATM/ATR,Apoptosis,Autophagy