Bioactivity:

CHMFL-ABL-121 is a highly potent inhibitor of type II ABL kinase (IC50s: 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein).

CAS nr:

2270879-07-5

Purity:

98%

Molecular Weight:

580,67

SMILES:

O=C(NC1=CC(C(F)(F)F)=C(CN2CCN(C)CC2)C=C1)CCSC3=CC(NN=C4/C=C/C5=CC=CC=N5)=C4C=C3

Formula:

C30H31F3N6OS

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling

Target:

Bcr-Abl,Bcr-Abl,Bcr-Abl