Bioactivity:

PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and

CAS nr:

1402438-74-7

Purity:

98%

Molecular Weight:

479,92

SMILES:

NC1=NC=C2C(N(C(C)(C)CO)C=C2C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=N1

Formula:

C23H22ClN7O3

Pathway:

Tyrosine Kinase/Adaptors

Target:

Trk receptor