Bioactivity:

PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNF_ production and has an anti-inflammatory effect. PF-3644022 also inhibits MK3 and p38 regulated/activated

CAS nr:

1276121-88-0

Purity:

98%

Molecular Weight:

374,46

SMILES:

O=C1C2=C(NC[C@@H](C)N1)C3=C(C=CC4=NC(C5=CN=C(C)C=C5)=CC=C34)S2

Formula:

C21H18N4OS

Pathway:

MAPK,Proteases/Proteasome,MAPK

Target:

MAPK,Serine Protease,p38 MAPK