Bioactivity:

AMG8380 is an orally active and less active enantiomer of AMG8379 served as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 (IC50s: 0.907 and 0.387 _M). AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels (

CAS nr:

1642112-32-0

Purity:

98%

Molecular Weight:

543,93

SMILES:

O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=CC(F)=C(C=C4OC)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O.[R]

Formula:

C25H16ClF2N3O5S

Pathway:

Others

Target:

Others