Bioactivity:

NAE-IN-M22 is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE).�NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells.�NAE-IN-M22 also can inhibit tumor growth in vivo.

CAS nr:

864420-54-2

Purity:

98%

Molecular Weight:

363,32

SMILES:

ClC1=CC=C(CCNC2CCN(CC3=CC=CC=C3)CC2)C(Cl)=C1

Formula:

C20H24Cl2N2

Pathway:

Ubiquitination,Apoptosis

Target:

E1/E2/E3 Enzyme,Apoptosis