Bioactivity:

BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than GSK3_.

CAS nr:

702675-74-9

Purity:

98%

Molecular Weight:

591,47

SMILES:

Ic1cnc(Nc2cc(NC(=O)N3CCCC3)ccc2)nc1NCCCNC(=O)c1cccs1

Formula:

C23H26IN7O2S

Pathway:

NF-_b,Autophagy,PI3K/Akt/mTOR signaling,Cell Cycle/Checkpoint,Cell Cycle/Checkpoint,Tyrosine Kinase/Adaptors

Target:

I_B/IKK,Autophagy,PDK,Chk,CDK,c-Kit