Bioactivity:

PF-05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.

CAS nr:

1235403-62-9

Purity:

98%

Molecular Weight:

500,35

SMILES:

O=S(C1=CC(Cl)=C(OC2=CC=C(Cl)C=C2C3=C(N)NN=C3)C=C1F)(NC4=CSC=N4)=O

Formula:

C18H12Cl2FN5O3S2

Pathway:

Membrane transporter/Ion channel

Target:

Sodium Channel