Bioactivity:

WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selectivity for mTOR is higher than PI3K_ (>100-fold) and PI3K_ (>500-fold).

CAS nr:

1062169-56-5

Purity:

98%

Molecular Weight:

495,53

SMILES:

COC(=O)Nc1ccc(cc1)c1nc2c(cnn2C2CCN(CC2)C(=O)OC)c(n1)N1CCOCC1

Formula:

C24H29N7O5

Pathway:

PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,Autophagy,Apoptosis

Target:

PI3K,mTOR,Autophagy,Apoptosis