Bioactivity:

TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.

CAS nr:

1802220-02-5

Purity:

98%

Molecular Weight:

355,37

SMILES:

Fc1cc2[C@@H](C)Nc3nc4c(cnn4cc3)C(=O)NC[C@@H](Oc2cc1)C

Formula:

C18H18FN5O2

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,Immunology/Inflammation,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors

Target:

ALK,ALK,ROS,Src,Src,Trk receptor