Bioactivity:

EGFR-IN-11 significantly suppresses the EGFR phosphorylation, induce the apoptosis, and arrest cell cycle at G0/G1.EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC50 of 18 nM for triple mutant EGFRL858R/T790M/C797S.

CAS nr:

T11158

Purity:

98%

Molecular Weight:

573,71

SMILES:

CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C=N3)N=C(NC5=CC=CC=C5)N4[C@H]6CN(CC6)S(C7CC7)(=O)=O

Formula:

C29H35N9O2S

Pathway:

Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors

Target:

EGFR,EGFR,EGFR