Bioactivity:

Lazertinib is an effective, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively.

CAS nr:

1903008-80-9

Purity:

98%

Molecular Weight:

554,64

SMILES:

COc1cc(N2CCOCC2)c(NC(=O)C=C)cc1Nc1nccc(n1)-n1cc(CN(C)C)c(n1)-c1ccccc1

Formula:

C30H34N8O3

Pathway:

Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors

Target:

EGFR,EGFR,EGFR