Bioactivity:

AM-0687 is a potent and selective PI3K_ inhibitor. AM-0687 has Cellular potency: pAKT IC50 = 0.7 nM; HWB, u (pAKT) IC 50 = 4.6 nM. Rat KLH: IgG ED50 -= 0.026 mg/kg; IgM ED50 = 0.016 mg/kg. Rat PK Clu = 2.3 L/hr/kg.

CAS nr:

1259522-94-5

Purity:

98%

Molecular Weight:

442,46

SMILES:

O=C(C1=C(C2=NC=CC=C2)C([C@@H](NC3=NC=NC(N)=C3C#N)C)=NC4=CC=C(F)C=C14)NC

Formula:

C23H19FN8O

Pathway:

Target: