Bioactivity:

EGFR mutant- in-1, A 5-methylpyrimidopyridone derivative are effective selective EGFRL858R/T790M/C797S mutant inhibitors with IC50 of 27.5 nM, which significantly weakened EGFRWT effect.

CAS nr:

T11164

Purity:

98%

Molecular Weight:

632,17

SMILES:

O=C1C(C2=CC=CC(F)=C2Cl)=C(C)C3=CN=C(NC4=CC=C(N5CCN(C)CC5)C(C)=C4)N=C3N1[C@H]6CN(C(CC)=O)CCC6

Formula:

C34H39ClFN7O2

Pathway:

JAK/STAT signaling,Tyrosine Kinase/Adaptors,Angiogenesis

Target:

EGFR,EGFR,EGFR