Bioactivity:

Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-_ converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-_ in vitro, ex vivo, and in vivo with IC50s

CAS nr:

287405-51-0

Purity:

98%

Molecular Weight:

414,5

SMILES:

CC1(C)[C@H](C(NO)=O)N(S(=O)(C2=CC=C(OCC#CCO)C=C2)=O)CCS1

Formula:

C17H22N2O6S2

Pathway:

Apoptosis,Proteases/Proteasome

Target:

TNF,MMP