Bioactivity:

LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).

CAS nr:

10538-99-5

Purity:

98%

Molecular Weight:

471,42

SMILES:

Nc1nc(=O)c2N3C(CN(C3=O)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2[nH]1

Formula:

C20H21N7O7

Pathway:

Metabolism,Cell Cycle/Checkpoint,DNA Damage/DNA Repair

Target:

DHFR,DHFR,DHFR