Bioactivity:

BMS-986158 is a potent BET inhibitor with IC50s of 6.6 and 5_nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively.

CAS nr:

1800340-40-2

Purity:

98%

Molecular Weight:

495,62

SMILES:

OC(C)(C)C1=CC=C2C(N([C@H](C3=CC=CC=C3)C4CCOCC4)C5=C2N=CC(C6=C(C)N=NN6C)=C5)=C1

Formula:

C30H33N5O2

Pathway:

Chromatin/Epigenetic

Target:

Epigenetic Reader Domain