Bioactivity:

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.

CAS nr:

331771-20-1

Purity:

98%

Molecular Weight:

513,59

SMILES:

COC1=C(OCCCN2CCOCC2)C=C2N=CN=C(NC3=CC=C(NC(=O)C4=CC=CC=C4)C=C3)C2=C1

Formula:

C29H31N5O4

Pathway:

MAPK,Tyrosine Kinase/Adaptors,Angiogenesis,Chromatin/Epigenetic,Cell Cycle/Checkpoint,Apoptosis

Target:

MEK,Src,Src,Aurora Kinase,Aurora Kinase,Apoptosis