Bioactivity:

OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.

CAS nr:

183320-51-6

Purity:

98%

Molecular Weight:

415,87

SMILES:

Cl.COCCOC1=CC2=C(C=C1OCCO)C(NC1=CC=CC(=C1)C#C)=NC=N2

Formula:

C21H21N3O4�HCl

Pathway:

Metabolism,Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling

Target:

Drug Metabolite,EGFR,EGFR,EGFR