Bioactivity:

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).

CAS nr:

1229582-33-5

Purity:

98%

Molecular Weight:

421,54

SMILES:

CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1

Formula:

C27H27N5

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling,Tyrosine Kinase/Adaptors,Angiogenesis,MAPK,Angiogenesis,Tyrosine Kinase/Adaptors,DNA Damage/DNA Repair,Metabolism,Angiogenesis,Chromatin/Epigenetic,Cell Cycle/Checkpoint,Tyrosine Kinase/Adaptors,Autophagy,Stem Cells,Cytoskeletal Signaling,Cell Cycle/Checkpoint,Tyrosine Kinase/Adaptors,Autophagy,Cell Cycle/Checkpoint,Tyrosine Kinase/Adaptors,MAPK

Target:

c-Met/HGFR,Bcr-Abl,Bcr-Abl,Bcr-Abl,VEGFR,VEGFR,MEK,Syk,Syk,DNA Alkylation,SGK,Src,Aurora Kinase,Aurora Kinase,Src,Autophagy,ROCK,ROCK,ROCK,Trk receptor,LRRK2,CDK,IGF-1R,MLK