Bioactivity:

PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977 is an orally active and selective HIF-2_ inhibitor (IC50: 9 nM). PT2977, as a second-generation HIF-2_ inhibitor, increases potency and improves pharmacokinetic profile.

CAS nr:

1672668-24-4

Purity:

98%

Molecular Weight:

383,34

SMILES:

N#CC1=CC(F)=CC(OC2=CC=C(S(=O)(C)=O)C3=C2[C@@H](F)[C@@H](F)[C@H]3O)=C1

Formula:

C17H12F3NO4S

Pathway:

Chromatin/Epigenetic,Angiogenesis

Target:

HIF,HIF