Bioactivity:

MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (_5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also inhibits the caspase-like (_1) and trypsin-like

CAS nr:

1072833-77-2

Purity:

98%

Molecular Weight:

361,03

SMILES:

B([C@H](CC(C)C)NC(=O)CNC(=O)c1c(ccc(c1)Cl)Cl)(O)O

Formula:

C14H19BCl2N2O4

Pathway:

Proteases/Proteasome,Apoptosis,Proteases/Proteasome,Ubiquitination,Autophagy

Target:

Caspase,Caspase,Proteasome,Proteasome,Autophagy